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KMID : 0370219930370060625
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Yakhak Hoeji
1993 Volume.37 No. 6 p.625 ~ p.630
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Bradykinin Antagonistic Activities of Antihistamine Agents Containing Piperazine Moiety
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정성현/Chung SH
이소영/윤혜숙/Lee SY/Yun HS
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Abstract
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Among the six antihistamine agents tested in this study, homochlorcyclizine showed the highest bradykinin antagonistic activity in the receptor binding assay as well as the isolated rat ileum assay. Schild plot analysis of bradykinin-induced ileal contraction in the presence of three different concentrations of homochlorcyclizine revealed a pA2=6.26, and a correlation coefficient of 0.984. Homochlorcyclizine of (lOOmcM final concentration) also showed 25% antagonistic activity in the receptor binding assay.
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KEYWORD
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